My anxiety and OCD always acts up more at night. I'm trying to sleep, brain, HUSH. It's so hard to explain to my boyfriend. I told him it's like two sides of you are arguing with each other in your head. You know what you are obsessing/anxious over is irrational but you can't stop. My Zoloft has helped so much with my depression, but I'm still having anxiety every night. The doctor said it will ease…I can only hope.